Number of proteins in the PhoP regulon

Range ~15 proteins
Organism Bacteria Salmonella typhimurium
Reference Alpuche-Aranda CM, Racoosin EL, Swanson JA, Miller SI. Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes. J Exp Med. 1994 Feb 1 179(2):601-8 link p.601 right column 3rd paragraph PubMed ID8294870
Primary Source [10] Miller SI, Mekalanos JJ. Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages. J Bacteriol. 1990 May172(5):2485-90.PubMed ID2185222
Comments P.601 right column 3rd paragraph: "The PhoP regulon also includes approximately 15 proteins that are repressed by a phoP locus mutation that results in constitutive pag transcription (phenotype PhoPc) (primary source)." Primary source abstract: "The phoP genetic locus is a two-component regulatory system (phoP-phoQ) that controls the expression of genes essential for Salmonella typhimurium virulence and survival within macrophages."
Entered by Uri M
ID 116147