Average pH values of organelles and compartments in mammalian cells

Range Table - link unitless
Organism Mammals
Reference Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6663 figure 2BPubMed ID24901537
Primary Source [92] Casey JR, Grinstein S, Orlowski J. Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol. 2010 Jan11(1):50-61. doi: 10.1038/nrm2820PubMed ID19997129
Comments P.6665 left column 3rd paragraph: "At optimal growth conditions, E. coli maintains an intracellular pH of 7.4–7.8, provided that the pH of the external environment is between 5.5 and 9.0 (refs 95-98). Using fluorescence imaging, approximate pH values of HeLa cytoplasm, mitochondria, endoplasmic reticulum, and Golgi were determined to be 7.4, 8.0, 7.5, and 6.6, respectively (ref 99). In a recent review, the pH values of various eukaryotic compartments and organelles were reported to be 7.2 for the cytosol, 7.2 for the nucleus (due to permeability), 7.2 for the endoplasmic reticulum, 6.7 for cis-Golgi cisterns and 6.0 at trans-Golgi networks, 8.0 in mitochondria, 7.0 in peroxisomes, 5.5 in secretory granules, 6.3 in early endosomes, 6.5 in recycling endosomes, 5.5 in late endosomes, and 4.7 in lysosomes (Figure 2B)(Primary source)."
Entered by Uri M
ID 115761