Fraction of mutations in cancers occurring in the UK attributed to different sources (42% of these cancer cases are preventable)

Range E (environmental factors) 29%: H (heredity) 5%: R (DNA replication errors) 66 %
Organism Human Homo sapiens
Reference Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017 Mar 24 355(6331):1330-1334. doi: 10.1126/science.aaf9011 p.1332 middle column and right column top paragraphPubMed ID28336671
Method Abstract: "[Investigators] studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world."
Comments P.1332 middle column: "When these data are normalized for the incidence of each of these 32 cancer types in the population, [investigators] calculate that 29% of the mutations in cancers occurring in the United Kingdom were attributable to E, 5% of the mutations were attributable to H, and 66% were attributable to R. Cancer Research UK estimates that 42% of these cancer cases are preventable."
Entered by Uri M
ID 115309