Number of Thyroid-stimulating hormone [TSH] cells removed daily in euthyroid and hypothyroid rats

Range euthyroid ~9,900: hypothyroid ~45,000 somatotroph cells/day
Organism Rat Rattus norvegicus
Reference DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 p.1179 left column 3rd paragraphPubMed ID436756
Method Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level."
Comments P.1179 left column 3rd paragraph: "From the product of the average rate of decrease for TSH cells (3.3%/day) and the number of these cells per pituitary in the steady state settings of euthyroidism and hypothyroidism (ref 11), [investigators] estimate that about 9,900 and 45,000 TSH cells are removed per day in the euthyroid and hypothyroid states, respectively."
Entered by Uri M
ID 115300