Number of type III secretion systems (ttss-1) and effector proteins expressed by a typical TTSS-1+ cell

Range 20 - 200 TTS apparatuses/cell: ~3-10×10^4 effector proteins/cell
Organism Bacteria Salmonella typhimurium
Reference Sturm A et al., The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog. 2011 Jul7(7):e1002143. doi: 10.1371/journal.ppat.1002143 p.7 left column top paragraphPubMed ID21829349
Primary Source [2] Schlumberger MC et al., Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A. 2005 Aug 30 102(35):12548-53 DOI: 10.1073/pnas.0503407102 [3] Winnen B et al., Hierarchical effector protein transport by the Salmonella Typhimurium SPI-1 type III secretion system. PLoS One. 2008 May 14 3(5):e2178. doi: 10.1371/journal.pone.0002178PubMed ID16107539, 18478101
Method Abstract: "Here, [investigators] studied in vitro the TTSS-1(+) phenotype at the single cell level using fluorescent protein reporters."
Comments P.7 left column top paragraph: "Typical TTSS-1+ cells are estimated to express 20–200 TTS apparatuses and approx. 3-10×10^4 effector proteins, amounting to a significant fraction of the total cellular protein [primary sources]."
Entered by Uri M
ID 115213