GABA concentration in brain

Value 1 mM
Organism Unspecified
Reference Krnjević, K. "Chemical nature of synaptic transmission in vertebrates." Physiological Reviews pp.418-540 :(1974) 54.2 p.446 top paragraph
Comments P.446 top paragraph: "Gamma-aminobutyric acid (GABA), on the other hand, which was not discovered as a brain constituent until 1950 (refs 45, 1044), in vertebrates is found in hardly any other tissues and is not a component of protein-although it is by no means a “new” compound, being a very common product of widespread photosynthetic and other metabolic reactions in microorganisms and plants (refs 11, 1228). Its relatively high concentration (10^-3M) in the brain suggested some special function, presumably related to neural activity, but there was no clue as to what this function might be." See also p.454 3rd paragraph: "Summary: GABA is found in substantial concentration (>10^-3M) in all regions of the CNS [central nervous system]. In its subcellular distribution it differs from Ach [AcetylCholine], being found mostly free in the cytoplasm and relatively little in vesicles, but nerve endings contain sufficient amounts for appreciable physiological effects."
Entered by Uri M
ID 115055