| Comments |
P.806 right column top paragraph: "Reactivity is also critically dependent on the environment of the oxidant and target, this is illustrated in Table 5, which provides rate constants for a number of oxidants with the same amino acid (Cys) in different environments–from free amino acid to the active site of specific enzymes. These data vary by ∼10^8 as a result of environmental and structural factors that make some Cys residues particularly reactive (e.g. in peroxiredoxins) compared with other proteins, the Cys-containing tripeptide glutathione GSH, and the free amino acid [primary sources 4–6]." |