Distribution of total plasma Magnesium concentrations ((MgT), from 0.65 to 0.95 mmol/L): protein-bound fraction (to albumin & globulins), chelated fraction & metabolically active ionized fraction (Mg-ion)

Range bound to albumin 25%: bound to globulins 8%: chelated 12%: Mg-ion 55% %
Organism Human Homo sapiens
Reference Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res. 2009 Dec22(4):235-46. doi: 10.1684/mrh.2009.0187 p.237 left columnPubMed ID20228001
Primary Source See link PubMed ID16808892, 12537985, 10727669
Comments P.236 right column: "Total plasma Mg concentrations (MgT), in relation to this tight control, are remarkably constant in healthy subjects throughout life and do not tend to change with aging [primary source 1, ref 6] (figure 2). MgT concentration ranges from 0.65 to 0.95 mmol/L. In the serum Mg exists in 3 forms: a protein-bound fraction (25% bound to albumin and 8% bound to globulins), a chelated fraction (12%), and the metabolically active ionized fraction (Mg-ion: 55%) [primary sources]. MgT, probably because of the large part bound to proteins or chelated, is not very sensitive in detecting subclinical Mg deficiencies."
Entered by Uri M
ID 114371