Number of ribonucleases encoded by genome

Range >20 ribonucleases
Organism Bacteria Escherichia coli
Reference Sørensen MA, Fehler AO & Svenningsen SL. Transfer RNA instability as a stress response in Escherichia coli: Rapid dynamics of the tRNA pool as a function of demand. RNA Biol. 2017 Oct 12: 0. doi: 10.1080/15476286.2017.1391440 p.8 bottom paragraphPubMed ID29023189
Comments P.8 bottom paragraph: "Given the demand-based working model described above, [investigators] assume that one or more “household” ribonucleases (RNases) are responsible for tRNA degradation during amino acid starvation, maybe aided by a factor that stimulates ribonucleolytic attack on the tRNA either by modification of the tRNA substrate or by up-regulation of RNase activity. The E. coli genome encodes more than 20 ribonucleases, including a number that participate in the processing of precursor transcripts to generate mature tRNAs, such as RNase E, RNase P, RNase PH and RNase T (reviewed in refs. 32, 33)."
Entered by Uri M
ID 114270