Infection case fatality rate

Range 45 - 90 %
Organism Ebola virus
Reference Prescott JB et al., Immunobiology of Ebola and Lassa virus infections. Nat Rev Immunol. 2017 Mar17(3):195-207. doi: 10.1038/nri.2016.138 p.196 right column 2nd paragraphPubMed ID28111475
Comments P.196 right column 2nd paragraph: "EBOV [Ebola virus] infections are severe in nature and associated with case fatality rates ranging from 45% to 90%. The incubation period is up to 21 days with abrupt onset of fever concurrent with malaise, fatigue, myalgia and headache. Subsequently, patients may develop nausea, vomiting, profuse watery diarrhoea, haemorrhages, meningoencephalitis, and hepatic and renal injury. Infection leads to systemic viral replication, target cell necrosis and the apoptosis of bystander lymphocytes, and it induces a cytokine storm that results in hypovolaemic shock and multi-organ failure [refs 3, 14, 15]."
Entered by Uri M
ID 114193