Oxidant range of reactivity-A range of 11 orders of magnitude for the second-order rate constants in the reaction of various oxidants with methionine (at neutral pH, in water)

Range Table - link M^-1×sec^-1
Organism Unspecified
Reference Sies H et al., Oxidative Stress. Annu Rev Biochem. 2017 Jun 20 86: 715-748. doi: 10.1146/annurev-biochem-061516-045037 p.722 table 3PubMed ID28441057
Primary Source Davies MJ. Protein oxidation and peroxidation. Biochem J. 2016 Apr 1 473(7):805-25. doi: 10.1042/BJ20151227PubMed ID27026395
Comments P.719 bottom paragraph: "Some of the reduction products of oxygen are of a free-radical nature, having a free electron (e.g., the superoxide anion radical and the hydroxyl radical), whereas hydrogen peroxide, the two-electron reduction product, is not a radical and as such is a chemically stable molecule. Electronically excited states comprise singlet molecular oxygen and excited carbonyl compounds, which are also nonradicals. Further biologically important reactive species are chlorine and bromine species such as hypohalous acids, hypochlorite, and chloramines. Detailed chemical properties of these molecules have been compiled in textbooks and reviews. Suffice it to say here that the chemical reactivities of the various reactive species shown in Table 2 vary by up to 11 orders of magnitude when assayed against a given target, an example is shown in Table 3."
Entered by Uri M
ID 114091