Comments |
P.262 left column 3rd paragraph: "Table 1 summarizes a few of the numerous studies in which melatonin has been effectively used to combat IR [ischemia/reperfusion] damage in the brain and in the heart. As seen in the table, the most common rodent model used to temporarily interrupt the blood supply to a focal area of the brain is middle cerebral artery occlusion (MCAO) with the usual doses of melatonin used to counter the associated neural damage being 4–10 mg/kg body weight (BW). This model is of interest since it is representative of the localized stroke that humans often experience." |