A summary of results of some published reports, which illustrate the beneficial effects of melatonin in experimental and clinical ischemia/reperfusion injury (stroke) in the brain and in the heart (heart attack)

Range Table - link
Organism Mammals
Reference Reiter RJ et al., Melatonin as an antioxidant: under promises but over delivers. J Pineal Res. 2016 Oct61(3):253-78. doi: 10.1111/jpi.12360 p.263 table 1PubMed ID27500468
Primary Source See refs beneath table
Comments P.262 left column 3rd paragraph: "Table 1 summarizes a few of the numerous studies in which melatonin has been effectively used to combat IR [ischemia/reperfusion] damage in the brain and in the heart. As seen in the table, the most common rodent model used to temporarily interrupt the blood supply to a focal area of the brain is middle cerebral artery occlusion (MCAO) with the usual doses of melatonin used to counter the associated neural damage being 4–10 mg/kg body weight (BW). This model is of interest since it is representative of the localized stroke that humans often experience."
Entered by Uri M
ID 114086