2 - 3 hours
||Rat Rattus norvegicus
||Baudouin-Cornu P, Lagniel G, Kumar C, Huang ME, Labarre J. Glutathione degradation is a key determinant of glutathione homeostasis. J Biol Chem. 2012 Feb 10 287(7):4552-61. doi: 10.1074/jbc.M111.315705 p.4552 right column bottom paragraphPubMed ID22170048
|| Lu S. C. (1999) Regulation of hepatic glutathione synthesis. Current concepts and controversies. FASEB J. 13, 1169–1183PubMed ID10385608
||Abstract: "Combining mathematical models and (35)S labeling, [investigators] analyzed Saccharomyces cerevisiae sulfur metabolism. This led [them] to the observation that GSH [glutathione] recycling is markedly faster than previously estimated. [They] set up additional in vivo assays and concluded that under standard conditions, GSH half-life is around 90 min."
||P.4552 right column bottom paragraph: "In mammalian cells GSH degradation occurs exclusively in the extracellular space. γ-Glutamyl-transpeptidase (γ-GT) cleaves GSH into cysteinylglycine (Cys-Gly) and a Glu residue that is transferred on another acceptor amino acid. Cys-Gly is further cleaved by a dipeptidase (for review see Ref. 1). GSH homeostasis is thus the result of its synthesis and utilization inside the cell, its export, and its degradation outside the cell, with a fast turnover (half-life of 2–3 h in the rat liver (primary source))."