Average lifetime of TSPs [thymus-seeding progenitors] and ETPs [early T lineage progenitors] combined

Range 9 - 12 days
Organism Mouse Mus musculus
Reference Krueger A, Ziętara N, Łyszkiewicz M. T Cell Development by the Numbers. Trends Immunol. 2017 Feb38(2):128-139. doi: 10.1016/j.it.2016.10.007 p.132 bottom paragraphPubMed ID27842955
Primary Source [42] H.E. Porritt, et al. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice J. Exp. Med., 198 (2003), pp. 957-962 DOI: 10.1084/jem.20030837PubMed ID12975459
Method Primary source [42] abstract: "Upon thymus entry, thymic-homing progenitors undergo distinct phases of differentiation as they migrate through the cortex to the capsule, suggesting that the signals that induce these differentiation steps may be stratified in corresponding cortical regions. To better define these regions, [investigators] transplanted purified stem cells into nonirradiated congenic recipients and followed their differentiation with respect to both tissue location and time."
Comments P.132 bottom paragraph: "TSPs and ETPs combined have been estimated by transplantation of BM [bone marrow]-derived progenitors to have an average lifetime of 9–12 days [primary source] during which they divide almost once per day. These data have recently been employed to generate a dynamical model of early T cell development to generate estimates for the residence time of cells within each thymocyte population and the cell cycle duration as well as probabilities of death or developmental progression [ref 49]."
Entered by Uri M
ID 113827