Estimated number of DNA-binding proteins

Range ~240 - 260 proteins
Organism Bacteria Escherichia coli
Reference Ishihama A, Functional modulation of Escherichia coli RNA polymerase. Annu Rev Microbiol. 2000 54: 499-518. DOI: 10.1146/annurev.micro.54.1.499 p.500 2nd paragraphPubMed ID11018136
Primary Source [85] Robison K, McGuire AM, Church GM. A comprehensive library of DNA-binding site matrices for 55 proteins applied to the complete Escherichia coli K-12 genome. J Mol Biol. 1998 Nov 27 284(2):241-54 DOI: 10.1006/jmbi.1998.2160PubMed ID9813115
Comments P.500 2nd paragraph: "From the genome sequence of E. coli, the total number of DNA-binding proteins that more or less influence transcription can be estimated to be ∼240–260 (primary source, N Fujita, unpublished data). Most of these DNA-binding proteins, which either activate or repress transcription of specific genes, interact directly with the RNA polymerase and modulate its specificity of transcription initiation (and elongation in some cases)."
Entered by Uri M
ID 113767