Enterocyte turnover in the small intestine

Range Table - link days
Organism Mouse Mus musculus
Reference Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 supplementary data pp.13-15 table 2PubMed ID25233858
Primary Source See pointers to refs in right column of table
Method Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A literature review together with statistical analysis was employed to establish enterocyte turnover in human and preclinical species." See "Method" column in table
Comments P.2018 right column bottom paragraph: "In the mouse, a total of 31 studies consisting of 651 healthy adult mice was identified reporting the enterocyte turnover in the small intestinal epithelia (Supplemental Table 2). The geometric WX [weighted mean] enterocyte turnover for the GI [gastrointestinal] tract was 2.81 (61.14, n = 169 mice) days."
Entered by Uri M
ID 113698