Fraction of transcription errors that cause an amino acid substitution

Range E. coli 68±1.46%: Buchnera aphidicola 80% %
Organism bacteria
Reference Traverse CC, Ochman H. Conserved rates and patterns of transcription errors across bacterial growth states and lifestyles. Proc Natl Acad Sci U S A. 2016 Mar 22 113(12):3311-6. doi: 10.1073/pnas.1525329113 p.3313 left column 2nd paragraphPubMed ID26884158
Comments P.3313 left column 2nd paragraph: "Effects of Transcription Errors on Protein Sequences: Given that each transcript can be translated—perhaps multiple times—into protein, [investigators] determined which transcription errors result in an amino acid substitution. On average, 68 ± 1.46% (SEM) of transcription errors cause an amino acid substitution in E. coli, whereas 80% of the transcription errors in Buchnera result in amino acid substitutions. If errors were to occur at random over the E. coli transcriptome, the probability of changing an amino acid is significantly higher than that actually incurred by transcription errors (76% vs. 68% pairwise Wilcoxon test, P < 0.008)."
Entered by Uri M
ID 113575