Mean lifespan of short-lived small blood lymphocytes

Range in rats and in haematologically normal man 4-7days: in patients with Hodgkin's disease 2.5-5.5days days
Organism Mammals
Reference Schick P, et al., Autotransfusion of 3H-cytidine-labelled blood lymphocytes in patients with Hodgkin's disease and non-Hodgkin patients. II. Exchangeable lymphocyte pools. Acta Haematol. 1975 53(4):206-18. p.214PubMed ID808930
Primary Source [4] Caffrey RW, Rieke WO, Everett NB. Radioautographic studies of small lymphocytes in the thoracic duct of the rat. Acta Haematol. 1962 28: 145-54. [21] Schick P et al., Kinetics of lymphocytes in Hodgkin's disease. Blut. 1973 Oct27(4):223-35.PubMed ID13875511, 4744339
Method Abstract: "The dilution in the circulating blood of lymphocytes lablled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin's disease (HD) stage II A-IV B, 5 of whom were untreated in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma."
Comments P.213 bottom paragraph: "The mean life span of short-lived small blood lymphocytes was reported to be 4-7 days in rats and haematologically normal man [primary source 4, unpublished data] and 2.5-5.5 days in patients with Hodgkin’s disease [primary source 21]."
Entered by Uri M
ID 113433