Fraction of basal ATP consumption in blood platelets that the "futile cycle" (see comments section) accounts for

Range ~7 %
Organism Human Homo sapiens
Reference Payrastre B et al., Phosphoinositides: key players in cell signalling, in time and space. Cell Signal. 2001 Jun13(6):377-87. p.377 right column bottom paragraphPubMed ID11384836
Primary Source [7] Verhoeven AJ et al., Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets. Eur J Biochem. 1987 Jul 1 166(1):3-9.PubMed ID3036523
Comments P.377 right column bottom paragraph: "In eukaryotic cells, it is classically admitted that phosphatidylinositol (PtdIns), phosphatidylinositol 4-monophosphate (PtdIns(4)P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) are kept in a steady-state level in the inner leaflet of the plasma membrane, because of continuous sequential phosphorylation/dephosphorylation reactions by specific kinases and phosphatases, which are not yet fully identified [ref 2], [ref 5]. This so-called “futile cycle” accounts for about 7% of the basal ATP consumption in human blood platelets [primary source]."
Entered by Uri M
ID 113407