Maximal P/O ratio (ATP made per O atom reduced)

Range 2 - 3 unitless
Organism Bacteria Escherichia coli
Reference Sauer U, Bailey JE. Estimation of P-to-O ratio in Bacillus subtilis and its influence on maximum riboflavin yield. Biotechnol Bioeng. 1999 Sep 20 64(6):750-4. DOI: 10.1002/(SICI)1097-0290(19990920)64:6<750::AID-BIT15>3.0.CO2-S link p.751 right column bottom paragraph PubMed ID10417225
Primary Source Gottschalk G. 1986. Bacterial metabolism, 2nd edition. New York: Springer-Verlag.
Method Abstract: "Simultaneous growth and riboflavin overproduction were investigated using a previously developed stoichiometric model of Bacillus subtilis metabolism. A fit of model predictions to experimental data was used to obtain estimates of fundamental energetic parameters of B. subtilis." P.750 right column bottom paragraph: "A previously constructed stoichiometric model of B. subtilis metabolism was used as published (Sauer et al., 1998). Briefly, mass balances on cellular metabolites provide a set of linear equations relating intracellular and external fluxes."
Comments P.751 right column bottom paragraph: "Electron Transport Chain Composition in B. subtilis: Compared with the Gram-negative bacteria, little is known about energy transduction in the respiratory metabolism of B. subtilis (Trumpower and Gennis, 1994). To see if there is any biological rationale for a lower P/O in B. subtilis than the maximum value of 2–3 assumed for Escherichia coli (primary source), [investigators] performed homology searches for respiratory chain components in the recently completed genome database of B. subtilis (Kunst et al., 1997) using the gapped Blast algorithm (Altschul et al., 1997)."
Entered by Uri M
ID 113246