Fraction of total body serotonin that is released into the gut by intestinal enterochromaffin cells

Range ~95 %
Organism Unspecified
Reference Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009 60: 355-66. doi: 10.1146/ p.361 left column 2nd paragraphPubMed ID19630576
Primary Source [8] Gershon MD, Tack J. 2007. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397–414 DOI: 10.1053/j.gastro.2006.11.002PubMed ID17241888
Comments P.361 left column 2nd paragraph: "Serotonin and the gastrointestinal system: Serotonin regulates digestion at multiple levels within the human GI [gastrointestinal] system and throughout the phylogenetic spectrum (Figure 2) (ref 58). Roughly 95% of total body serotonin is released into the gut by intestinal enterochromaffin cells (primary source), but serotonin is involved at the very moment that food enters the body. Activation of taste-bud cells on the tongue causes serotonin release onto sensory afferent nerves (ref 59) that transmit taste information to the CNS. Once food enters the GI tract, it is propelled along by peristaltic waves-these waves, as well as intestinal motility and secretion, are modulated by serotonin (reviewed extensively in primary source). For example, intestinal serotonin regulates pancreatic enzyme secretion (ref 60), a mechanism by which the gut may communicate exocrine enzyme needs to the pancreas based on GI contents."
Entered by Uri M
ID 113115