Fraction of overall mass that is extracellular fluid and extracellular solids

Range extracellular fluid 25%: extracellular solids 7% %
Organism Human Homo sapiens
Reference Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol. 2016 Aug 19 14(8):e1002533. doi: 10.1371/journal.pbio.1002533. P.8 2nd paragraphPubMed ID27541692
Primary Source [37] Shen W et al, Four-compartment cellular level body composition model: comparison of two approaches. Obes Res. 2005 Jan13(1):58-65. DOI: 10.1038/oby.2005.8PubMed ID15761163
Method Primary source abstract: "Research methods and procedures: Total body potassium (TBK) model: BCM from TBK by whole-body counting-ECF(TBK)=LST-[BCM(TBK)+0.73 x osseous mineral (Mo)]. Bromide model: ECF from sodium bromide dilution-BCM(BROMIDE)=LST-(ECF(BROMIDE)+0.73xMo) Mo and LST measurements came from DXA. The two approaches were evaluated in 99 healthy men and 118 women." BCM=body cell mass, ECF=extracellular fluid, LST=lean soft tissue, DXA=Dual-energy X-ray absorptiometry
Comments P.8 2nd paragraph: "Mass-Centered Approach as Sanity Check for Cell Count: It is prudent in making such estimates to approach the analysis from different angles. In that spirit, [investigators] now ask does the cumulative mass of the cells counted fall within the expected range for a reference adult? To properly tackle that question, [they] first need to state what the anticipated result is, i.e., total body cell mass. For a reference man mass of 70 kg, 25% is extracellular fluid [primary source], another 7% is extracellular solids [primary source], thus [they] need to account for ≈46 kg of cell mass (including fat)."
Entered by Uri M
ID 113004