| Comments |
P.70 right column bottom paragraph: "Regulation of organelle trafficking by MCSs [membrane contact sites]. The formation of the MCSs does not only affect the structure of the ER itself but has also been implicated in regulating the trafficking and localization of both endosomes and mitochondria. Following budding from the plasma membrane, endosomes traffic along microtubules towards the microtubule organizing centre (MTOC) and mature on the way, transitioning from early endosomes to late endosomes, to finally fuse with the lysosome [ref 26]. A large percentage of endosomes maintain contact with the ER as they traffic (Fig. 2b,c). In fact, approximately 53% of all early endosomes, and a staggering 99% of late endosomes, remain in contact with the ER during trafficking." P.75 legend to figure 2c: "Endosomes mature as they traffic from the cell periphery along microtubules to the cell centre. ER–endosome contact increases as endosomes mature, with 53% of early endosomes (EEs marked by RAB5) and 99% of LEs (marked by RAB7)
remaining in contact with the ER during trafficking." |