Gap distance between ER and endosome and ER and mitochondria

Range ER and endosome 3-15nm: ER and mitochondria 6-15nm nm
Organism Mammals
Reference Phillips MJ, Voeltz GK. Structure and function of ER membrane contact sites with other organelles. Nat Rev Mol Cell Biol. 2016 Feb17(2):69-82. doi: 10.1038/nrm.2015.8. p.69 right column 2nd paragraphPubMed ID26627931
Primary Source [7] Alpy, F. et al. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. J. Cell Sci. 126, 5500–5512 (2013). doi: 10.1242/jcs.139295. [8] Csordás, G. et al. Structural and functional features and significance of the physical linkage between ER and mitochondria. J. Cell Biol. 174, 915–921 (2006). DOI: 10.1083/jcb.200604016 [9] Friedman, J. R. et al. ER tubules mark sites of mitochondrial division. Science 334, 358–362 (2011). doi: 10.1126/science.1207385.PubMed ID24105263, 16982799, 21885730
Comments P.69 right column 2nd paragraph: "Electron micrographs have also been used to measure the distance between the ER and the apposing organelles. The gap distances are quite similar: 3–15 nm for ER–endosome [primary source 7] and 6–15 nm for ER–mitochondria primary sources 8, 9]. Such short tethering distances allow channelling of smooth ER materials, such as lipids and Ca2+ (discussed below)." Primary sources studied: [7] HeLa cell [8] RBL-2H3 (Rat Basophilic Leukemia, cancerous basophil) cells [9] COS 7 cells, (African green monkey)
Entered by Uri M
ID 112889