| Value |
6
lethal disruptions/79 random disruptions
|
| Organism |
Bacteria Bacillus subtilis |
| Reference |
Koonin EV. How many genes can make a cell: the minimal-gene-set concept. Annu Rev Genomics Hum Genet. 2000 1: 99-116. DOI: 10.1146/annurev.genom.1.1.99 p.100 3rd paragraphPubMed ID11701626
|
| Primary Source |
Itaya M. 1995. An estimation of minimal genome size required for life. FEBS Lett. 362: 257–60PubMed ID7729508
|
| Comments |
P.100 3rd paragraph: "A remarkable experimental study that resulted in an estimation of the minimal genome size was published at the end of the pregenomic era. Itaya has shown that of 79 random gene disruptions in Bacillus subtilis, only 6 were lethal (primary source). Furthermore, even simultaneous insertions into 33 loci have produced a viable bacterium." |
| Entered by |
Uri M |
| ID |
112736 |