| Range |
in stomach body ~7: in pyloric antrum 3: in small intestine crypt-villus cells ~0.5: in colon ~0.4 %
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| Organism |
Mouse Mus musculus |
| Reference |
Karam SM, Lineage commitment and maturation of epithelial cells in the gut. Front Biosci. 1999 Mar 15 4: D286-98. p.286 right column top paragraph, p.294 right column 3rd paragraphPubMed ID10077541
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| Primary Source |
[13] S.M. Karam & C.P. Leblond: Identifying and counting epithelial cell types in the "corpus " of the mouse stomach. Anat Rec 232, 231-46 (1992) [31] H. Cheng & C.P. Leblond: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cells. Am J Anat 141, 461-80 (1974) [57] E.R. Lee: Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of pit cells. Am J Anat 172, 225-40 (1985) [71] S. Tsubouchi & C.P. Leblond: Migration and turnover of entero-endocrine and caveolated cells in the epithelium of the descending colon, as shown by radioautography after continuous infusion of 3H-thymidine into mice. Am J Anat 156, 431-52 (1979)PubMed ID1546802, 4440632, 3993598, 525623
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| Comments |
P.294 right column 3rd paragraph:"11. Enteroendocrine cell lineages: The peptide- or polypeptide-producing enteroendocrine cell lineages are scattered throughout the gut epithelium. Members of these lineages usually occur singly along the gut epithelium. In mice, they represent about 7% of all cells in the stomach body (primary source 13) and 3% in the pyloric antrum (primary source 57). In the small intestine, they are more abundant in the crypts than in the villi and generally form about 0.5% of all crypt-villus cells (primary source 31). They form about 0.4% of cells in the colon (primary source 71). The identification of enteroendocrine cells of different lineages depends on the size, shape, electron density and immunocytochemical specificity of their secretory granules (ref 72). After a long debate about the neuronal vs. epithelial origin of these cells, it has been established that they share a common stem cell with other epithelial lineages in the gut (refs 73-77). Thus, enteroendocrine cells represent several cell lineages which originate from the epithelial stem cells of the gut." |
| Entered by |
Uri M |
| ID |
112583 |