Rate constant of polymerization of ATP actin onto the barbed end of an actin filament

Range 2×10^6 - 8×10^6 M^-1×sec^-1
Organism Generic
Reference Northrup SH, Erickson HP. Kinetics of protein-protein association explained by Brownian dynamics computer simulation. Proc Natl Acad Sci U S A. 1992 Apr 15 89(8):3338-42. p.3338 left column bottom paragraphPubMed ID1565624
Primary Source [1] Pollard, T. D. & Cooper, J. A. (1986) Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu. Rev. Biochem. 55, 987-1035.PubMed ID3527055
Method Abstract: "In the present study, the Brownian dynamics simulation method is used to compute the rate of association of neutral spherical model proteins with the stated docking criteria."
Comments p.3338 left column bottom paragraph: "The polymerization of ATP actin onto the barbed end of an actin filament occurs with k2 = 2-8×10^6×M^-1×s^-1 (primary source)."
Entered by Uri M
ID 112536