Increase in succinate oxidase mitochondrial fraction in skeletal muscle before & after exercise in elderly

Value 62 % Range: ±13 %
Organism Human Homo sapiens
Reference Menshikova EV et al., Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci. 2006 Jun61(6):534-40. abstract & p.537 left column 3rd paragraphPubMed ID16799133
Method Abstract: "[Investigators] examined the effects of exercise on skeletal muscle mitochondria in older (age = 67.3 +/- 0.6 years) men (n = 5) and women (n = 3)."
Comments Abstract: "Succinate oxidase activity, complexes 2-4 of the electron transport chain (ETC), increased from 0.13 +/- 0.02 to 0.20 +/- 0.02 U/mU CK (p <.01). This improvement was more pronounced (p <.05) in subsarcolemmal (127 +/- 48%) compared to intermyofibrillar (56 +/- 12%) mitochondria." P.536 right column bottom paragraph to p.537 right column top paragraph: "Mitochondrial ETC activity: Cardiolipin and mtDNa provide complimentary assessments of mitochondria content. To further assess the potential effect of exercise training, electron transport chain (ETC) activity, a functional measure, was assessed: specifically that of NADH oxidase and succinate oxidase, which represents mitochondria ETC activity from Complexes I to IV and II to IV, respectively. In response to intervention, activity of NADH oxidase in the total mitochondria fraction was approximately doubled (Figure 3). Succinate oxidase in the total mitochondria fraction increased (p<0.01) by 62 ± 13% (Figure 3) from 0.13 ± 0.02 to 0.20 ± 0.02 U·mU CK^−1. The magnitude of these increases corresponded with the increase in the content of both total mtDNA and cardiolipin. This suggests that the increased mitochondrial content corresponded with the overall increase in mitochondria function in skeletal muscle."
Entered by Uri M
ID 112465