Turnover rate for the replacement of the entire epithelium

Range 3 - 4 days
Organism Metazoa animals
Reference Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992 Nov119(3):493-501. p.499 left columnPubMed ID1400587
Primary Source Wright, N., and M. Alison. 1984. The Biology of Epithelial Cell Populations. Clarendon Press, Oxford. 537-891 and 981-1004.
Method pulse-chase experiments
Comments P.499 left column:"[Investigators'] prime objective in this work was to correlate the pattern of TUNEL [the method of TdT-mediated dUTP-biotin nick end labeling, see Method section in BNID 112334] staining in situ with data about systems in which PCD [programmed cell death] existence was already suspected through other means. The small intestine epithelium is typified by a high turnover rate (3-4 d for the replacement of the entire epithelium) and well-defined architecture of repetitive proliferating units where the location of cells which are about to be disposed, is known through pulse-chase experiments (summarized by primary source)."
Entered by Uri M
ID 112335