mRNA velocity in embryo

Value 0.1 µm/sec
Organism Fruit fly Drosophila melanogaster
Reference Gumy LF, Katrukha EA, Kapitein LC, Hoogenraad CC. New insights into mRNA trafficking in axons. Dev Neurobiol. 2014 Mar74(3):233-44. doi: 10.1002/dneu.22121. p.240 left column 4th paragraphPubMed ID23959656
Primary Source Bullock SL, Nicol A, Gross SP, Zicha D. 2006. Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity. Curr Biol 16: 1447–1452.PubMed ID16860745
Comments p.240 left column 4th paragraph:"Depending on the probability of anterograde runs, the drift velocity can be anywhere between zero (for equal probabilities) or ∼1 µm/s (the typical speed of a plus-end directed motor, which will be the effective speed of mRNPs [messenger ribonucleoproteins] if no retrograde runs occur). Measurements in Drosophila embryos reported a net mRNA velocity of 0.1 µm/s (primary source), suggesting that for these mRNPs the probability of anterograde runs is 55%."
Entered by Uri M
ID 112211