Synthesis and degradation rate constant of C8-HSL (C8-homo-serine lactone) in the ain system

Range synthesis rate 7,100nM/hr: degradation rate 0.53/hour
Organism Bacteria Vibrio fischeri
Reference Pai A, You L: Optimal tuning of bacterial sensing potential. Molecular systems biology 2009, 5(286) :286 doi: 10.1038/msb.2009.43. Supplementary Text 2 p.26 top paragraphPubMed ID19584835
Primary Source Gilson L, Kuo A, Dunlap PV (1995) AinS and a new family of autoinducer synthesis proteins. Journal of bacteriology 177: 6946-6951. AND Kaufmann GF et al., Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A. 2005 Jan 11 102(2):309-14. AND Lupp C, Ruby EG (2004) Vibrio fischeri LuxS and AinS: comparative study of two signal synthases. Journal of bacteriology 186: 3873-3881.PubMed ID7592489, 15623555, 15175301
Comments Supplementary Text 2 p.26 top paragraph:"ain system. (Type I)-The ain system signal C8-HSL controls the expression of colonization factors and inhibits luminescence at low cell densities (primary sources Gilson et al., 1995 Lupp & Ruby, 2004). Synthesis rate: k=7.1×10^3nM/hr (see note on signal synthesis) Degradation rate constant: From the hydrolysis rate (primary source Kaufmann et al., 2005) of C8-HSL, da=1.48×10^-5s^-1 = 0.53/hr."
Entered by Uri M
ID 112004