Average translation initiation rate

Value 5 1/min/mRNA
Organism Bacteria Escherichia coli
Reference Pai A, You L: Optimal tuning of bacterial sensing potential. Molecular systems biology 2009, 5(286) :286 doi: 10.1038/msb.2009.43. Supplementary Text 2 p.23 top paragraphPubMed ID19584835
Primary Source Kennell D, Riezman H (1977) Transcription and translation initiation frequencies of the Escherichia coli lac operon. Journal of molecular biology 114: 1-21. AND Neidhardt FC (1987) Escherichia Coli and Salmonella Typhimurium: Cellular and Molecular Biology. American Society for Microbiology.PubMed ID409848
Comments Supplementary Text 2 p.23 top paragraph:"Thus peptide and mRNA elongation times can be ignored in comparison with transcription and translation initiation rates. An average translation initiation rate (primary sources) of 5 min^-1 from each mRNA gives a constitutive signal peptide synthesis rate of about 10^4 molecules hr^-1 or k = 10^4 nM hr^-1 (1 nM≈1 molecule per cell volume of 10^-15 l)."
Entered by Uri M
ID 112001