Typical transcription initiation rate

Value 20 1/min/gene
Organism Bacteria Escherichia coli
Reference Pai A, You L: Optimal tuning of bacterial sensing potential. Molecular systems biology 2009, 5(286) :286 doi: 10.1038/msb.2009.43. Supplementary Text 2 p.23 top paragraphPubMed ID19584835
Primary Source Kennell D, Riezman H (1977) Transcription and translation initiation frequencies of the Escherichia coli lac operon. Journal of molecular biology 114: 1-21. AND Neidhardt FC (1987) Escherichia Coli and Salmonella Typhimurium: Cellular and Molecular Biology. American Society for Microbiology. AND Tadmor AD, Tlusty T (2008) A Coarse-Grained Biophysical Model of E. coli and Its Application to Perturbation of the rRNA Operon Copy Number. PLoS computational biology 4: e1000038. doi: 10.1371/journal.pcbi.1000038.PubMed ID409848, 18437222
Comments Supplementary Text 2 p.23 top paragraph:"The synthesis rate of signal peptides in QS [quorum sensing] systems has not been measured. A typical transcription initiation rate (primary sources) of 20 min^-1 at a gene with an average mRNA half-life (BNID 111998) of 1 min, gives a steady state estimate of 30 mRNAs per cell."
Entered by Uri M
ID 111997