Degradation rate of the homoserine lactone 3-Oxo-C6-AHL in vivo

Range ~0.005 - ~0.02 1/min
Organism bacteria
Reference Weber M, Buceta J. Noise regulation by quorum sensing in low mRNA copy number systems. BMC Syst Biol. 2011 Jan 20 5 :11. doi: 10.1186/1752-0509-5-11. p.7 left column top paragraphPubMed ID21251314
Primary Source [46] Pai A, You L: Optimal tuning of bacterial sensing potential. Molecular systems biology 2009, 5(286) :286 doi: 10.1038/msb.2009.43.PubMed ID19584835
Comments p.7 left column top paragraph:"The degradation rate of the homoserine lactone 3-Oxo-C6-AHL has been measured in vitro revealing that this autoinducer is rather stable: ~ 3·10^−4 min^−1 [BNID 111994]. Measurements of the degradation rate of other AHL autoinducers show similar results. Based on experimental data and mathematical modeling, the degradation rate of the signaling molecule in vivo has been also estimated [primary source]. Depending on the pH of the medium, the latter ranges from ~5·10−^3 min^−1 to ~2·10^−2 min^−1." AHL=acyl homo- serine lactones
Entered by Uri M
ID 111995