Typical protein half-life

Range ~20 hours
Organism bacteria
Reference Moran MA et al., Sizing up metatranscriptomics. ISME J. 2013 Feb7(2):237-43. doi: 10.1038/ismej.2012.94. p.239 right column top paragraphPubMed ID22931831
Primary Source Koch AL, Levy HR. (1955). Protein turnover in growing cultures of Escherichia coli. J Biol Chem 217: 947–958. & Mandelstam J. (1957). Turnover of protein in growing and non-growing populations of Escherichia coli. Biochem J 6: 110–119. & Borek E, Ponticorvo L, Rittenberg D. (1958). Protein turnover in microorganisms. Proc Natl Acad Sci USA 44: 369–374.PubMed ID13271454, 13535591, 16590208
Comments p.239 right column top paragraph:"However, the most important factor responsible for poor mRNA–protein correlations is the long half-life of proteins relative to mRNAs. A typical bacterial protein half-life is ~20 h (primary sources), which is about two orders of magnitude longer than an mRNA half-life. Thus, most proteins persist in a bacterial cell long after the mRNAs that encoded them have been degraded."
Entered by Uri M
ID 111930