| Comments |
p.365 right column 2nd paragraph:"The primate specific Alu sequences are the dominant short interspersed nuclear element (SINEs) in the primate genomes (International Human Genome Sequencing Consortium 2001 Cordaux and Batzer 2009). Humans have about a million copies of Alu, roughly 300 bp long each, accounting for ~10% of their genome. Since these repeats are so common, especially in gene-rich regions (Korenberg and Rykowski 1988), pairing of two oppositely oriented Alus located in the same pre-mRNA structure is likely. Such pairing produces a long and stable dsRNA structure, an ideal target for the ADARs [adenosine deaminases acting on RNA]. Indeed, recent studies have shown that Alu repeats account for >99% of editing events found so far in humans (Athanasiadis et al. 2004 Blow et al. 2004 Kim et al. 2004 Levanon et al. 2004 Ramaswami et al. 2012, 2013)." |