Lifetime cancer incidence and parameters related to the normal stem cells that are precursors of these cancers

Range Table - link
Organism Human Homo sapiens
Reference Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015 Jan 2 347(6217):78-81. doi: 10.1126/science.1260825. Supplementary Materials pp.13-15 table S1PubMed ID25554788
Primary Source Supplementary material p.3 top paragraph:"In general, the data are from ( and link results_merged/topic_lifetime_risk.pdf). If the data were not available there, [investigators] used,, or individual publications addressing a specific (typically rare) type of cancer."
Comments Supplementary material p.3 top paragraph:"The parameters listed in Table S1 correspond to the average size of the relevant normal tissues and were obtained from the literature directly or calculated using values from the literature. The references are provided below in the sections describing each cancer type. When available, some tissues estimates have been given for both specific anatomic locations as well as for the overall tissue (e.g. osteosarcoma). Lifetime incidences are all based on U.S. data." Supplementary p.13 heading of table S1:"Lifetime cancer risk and parameters related to the normal stem cells that are precursors of these cancers. “Stem cells” denote the self-renewing cell population responsible for the homeostasis of the relevant cells in the indicated tissues. Lifetime parameters were obtained from estimates of the frequency of tissue self-renewal, assuming an average lifespan of 80 years. The definitions for the parameters s, d, and lscd are provided in the Statistical Analysis section of the Materials and Methods section [pp.10-11 link ]. The literature sources for the parameters listed in this Table are provided for each cancer type in the Materials and Methods section." Note that table has 3 pages. See note beneath table
Entered by Uri M
ID 111704