Stacking and base pairing contributions to DNA polymer stability under different ambient conditions

Range Table - link
Organism Generic
Reference Yakovchuk P, Protozanova E, Frank-Kamenetskii MD. Base-stacking and base-pairing contributions into thermal stability of the DNA double helix. Nucleic Acids Res. 2006 Jan 31 34(2):564-74. p.572 table 1PubMed ID16449200
Method p.569 right column top paragraph:"[Investigators] obtain stacking free energy parameters by studying the equilibrium between stacked and unstacked form of DNA nick schematically presented in Figure 1a. The DNA molecule in the stacked state is very close the molecule without the lesion (42–49)."
Comments p.571 right column 2nd paragraph:"The horizontal lines give the mean values of base pairing parameters at 15 mM Na+ of ?G[BP]A•T=0.57kcal/mol and ?G[BP]G•C=-0.11kcal/mol. [Investigators] conclude that stability of the DNA polymer with respect to strand separation is mainly determined by stacking interactions with base pairing being destabilizing (A•T pairs) or contributing almost nothing (G•C-pairs) (Table 1)." See notes beneath table
Entered by Uri M
ID 111667