Postsynaptic area

Range 0.03 - 0.1 μm^2
Organism Rat Rattus norvegicus
Reference Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.767 right column top paragraphPubMed ID22958818
Primary Source Momiyama, A. et al., (2003). The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats. J. Physiol. 549, 75–92. & Nusser, Z.R. et al., (1998). Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21, 545–559.PubMed ID12665613, 9768841
Comments p.767 right column top paragraph:"For a postsynaptic area of 0.03 to 0.1 (µm)^2 (primary sources), 100 receptors would imply a density of 1,000–3,300 receptors /(µm)^2 to which NMDA and metabotropic receptors must also be added." NMDA=N-Methyl-D-aspartic acid or N-Methyl-D-aspartate. AMPA=a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Entered by Uri M
ID 111655