Composition of lymphocyte subsets in human organs and fluids

Range Table - link
Organism Human Homo sapiens
Reference Westermann J, Pabst R. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin Investig. 1992 Jul70(7):539-44. p.540 table 1PubMed ID1392422
Primary Source See pointers to refs on right of table
Method Abstract:"...reports on the frequencies and the absolute numbers of B and T lymphocyte subsets within various human tissues and fluids have been collected from a wide variety of journals and are briefly summarized here."
Comments p.539 left column bottom paragraph:"Even under physiological circumstances it is not only the classical lymphoid organs such as the thymus, lymph nodes and spleen which contain lymphocytes, but also a variety of non-lymphoid organs, for instance the lung, gut and skin (Table 1). Lymphocytes also occur in many body fluids (Table 1), indicating a unique feature of these cells: they are mobile and able to function both solitarily and in close collaboration with other lymphoid and non-lymphoid cells [ref 52]." p.539 right column 2nd paragraph:"In most tissues and fluids the different lymphocyte subsets have a unique relationship (Table 1). Heterogeneity in the composition is more pronounced between B and T lymphocytes than between CD4+ and CD8+ T lymphocytes. This can be seen in the T/B and CD4+/CD8+ ratios, the former ranging from 0.5 to 95, the latter from 0.2 to 3. In Table 1 the lymphocytes have been subdivided into B and T lymphocytes and again into CD4+ and CD8+ cells, the distribution of these cells having been investigated most frequently." See notes beneath table
Entered by Uri M
ID 111619