Number of osteocytes replenished throughout the skeleton on a daily basis

Value 9.1e+6 osteocytes/day Range: Table - link osteocytes/day
Organism Human Homo sapiens
Reference Buenzli PR, Sims NA. Quantifying the osteocyte network in the human skeleton. Bone. 2015 Jun75: 144-50. doi: 10.1016/j.bone.2015.02.016. abstract, p.146 table 2, p.147 right column 2nd paragraph & p.148 left column bottom paragraphPubMed ID25708054
Method P.145 left column bottom paragraph:"[Investigators] combined data from the published literature with arithmetic calculations and mathematical models to provide novel quantifications of the osteocyte network system. Quantities taken from the literature and used in these quantifications are listed in Table 1 [BNID 111544] with their source. The major quantities derived in this paper are listed in Table 2 with the formula used to calculate them. Table 3 [BNID 111546] summarizes how these quantities compare with other organ systems in the body."
Comments Abstract:"Finally, based on the average speed of remodelling in the adult, [investigators] calculate that 9.1 million osteocytes are replenished throughout the skeleton on a daily basis, indicating the dynamic nature of the osteocyte network." p.147 right column 2nd paragraph:"Although some osteocytes, such as those in the inner ear, may exist for as long as human life [ref 38], the majority are regularly removed and replaced due to the renewal of the bone matrix during remodelling. Parfitt [ref 25, Table 7] estimated the average skeletal remodelling rate (Rem.R) to be 7.6%/year (combining both cortical and trabecular turnover rates). Over the entire human skeleton bone volume (BV), this corresponds to a volume of renewed bone matrix of 133 cm^3/year (0.36 cm^3/day). Assuming this renewed bone to contain the same density of osteocytes, this corresponds to the replacement of 2.66 × 10^9–3.99 × 10^9 (average 3.33 billion) new osteocytes per year (9.1 million per day)." p.148 left column bottom paragraph:"A large number of osteocytes are replaced rapidly by remodelling — an estimated 9.1 million per day. This level of replacement falls below that of red blood cells (at 34.6 billion per day) [ref 50], but is far greater than the level of renewal estimated for hippocampal neurons (ref 700 per day) [ref 51]."
Entered by Uri M
ID 111552