| Method |
"Nonisotopic
methods
gave
the
first
estimates
of
platelet
lifespan (refs 1-3):
the
rate
of
disappearance
of
platelets
after
megacaryocytic aplasia
produced
by
X
ray
or
chemotherapy
(experimental
in
animal,
accidental
in
man)
the
rate
at
which
platelets
were
replaced
after
their
depletion
by
plasmapheresis
or
drugs-
the
number
of
circulating
platelets
after
injection
of
platelets
in
thrombopenic
or
aplastic
subjects
and
survival
of
morphologically
abnormal
platelets
in
normal
subjects.
Although
imprecise,
all
these
techniques
gave
an
estimate
of
platelet
lifespan
between
5
to
10
days." |