Rates of rhodopsin regeneration

Range arrestin-/- mice 0.8%/min: normal mice 1.0%/min %/min
Organism Mouse Mus musculus
Reference Saari JC. Biochemistry of visual pigment regeneration: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2000 Feb41(2):337-48. p.343 left column 3rd paragraphPubMed ID10670460
Method "...[researchers] examined the composition of retinoids during bleaching and regeneration in arrestin-/- mice. These animals were born and raised in the dark and subjected to flash bleaching followed by a recovery period in the dark. The distribution of visual cycle retinoids observed before and after a flash is very similar to that seen with normal mice (not shown)."
Comments "The recovery of 11-cis-retinal in the dark was slower in arrestin-/- mice than in normal mice (0.6 and 1.1% per minute, respectively. Fig. 10). However, the rates of rhodopsin regeneration were similar (0.8% per minute and 1% per minute, respectively)."
Entered by Uri M
ID 111399