Ratio of NADPH to nicotinamide adenine dinucleotide phosphate (NADP) in dark-adapted retina of rabbit and monkey

Value 0.3 unitless
Organism Mammals
Reference Saari JC. Biochemistry of visual pigment regeneration: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2000 Feb41(2):337-48. p.341 right column bottom paragraphPubMed ID10670460
Primary Source Matchinsky FM. Quantitative histochemistry of nicotinamide adenine nucleotides in retina of monkey and rabbit. J Neurochem. 1968 15: 643–657.PubMed ID4386358
Method Quantitative histochemistry
Comments "Studies of glucose metabolism emphasized that ROSs [rod outer segments] were capable of producing NADPH through the pentose phosphate pathway in amounts sufficient to account for reduction of all-trans-retinal.[ref 54] However, in dark-adapted rabbit and monkey retina, the ratio of NADPH to nicotinamide adenine dinucleotide phosphate (NADP) was reported to be 0.3, [primary source] indicating that the pathway would have to be activated for reduction to occur. In vivo [13C] nuclear magnetic resonance studies of rabbit retina have demonstrated an activation of the pentose phosphate pathway in constant light.[ref 56]"
Entered by Uri M
ID 111398