Lipid composition of synaptic vesicle

Range See Comments section % wt/wt
Organism Cow Bos Taurus
Reference Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci. 2004 27: 509-47. DOI: 10.1146/annurev.neuro.26.041002.131412 p.523 2nd paragraphPubMed ID15217342
Primary Source Benfenati F, Greengard P, Brunner J, Bahler M. 1989. Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers. J. Cell Biol. 108: 1851–62PubMed ID2497105
Comments [40% phosphatidylcholine,32%phosphatidylethanolamine,12% phosphatidylserine, 5% phosphatidylinositol, 10% cholesterol, wt/wt] "Synaptic vesicles are uniformly small (~20-nm radius), abundant organelles whose only known function is to take up and release neurotransmitters. They are relatively simple because only a limited number of proteins fit into a sphere of 40-nm diameter. Purified vesicles have a protein:phospholipid ratio of 1:3 with an unremarkable lipid composition (40% phosphatidylcholine,32%phosphatidylethanolamine,12% phosphatidylserine, 5% phosphatidylinositol, 10% cholesterol, wt/wt Primary Source). Many proteins that have been associated with synaptic vesicles are probably present only on a subset of vesicles or bind transiently to the vesicles, and the number of proteins that are constitutive parts of all synaptic vesicles may be comparatively small (i.e., less than 50)."
Entered by Uri M
ID 111283