| Range |
150 - 300 kb
|
| Organism |
African clawed frog Xenopus laevis |
| Reference |
Conti C, Saccà B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell. 2007 Aug18(8):3059-67. p.3059 right column 2nd paragraphPubMed ID17522385
|
| Primary Source |
Hyrien, O., Maric, C., and Mechali, M. (1995). Transition in specification of embryonic metazoan DNA replication origins. Science 270, 994–997.PubMed ID7481806
|
| Comments |
"In early Xenopus embryos, transcription is repressed
and DNA replication starts at nonspecific sites every 5–15
kb. The exit from midblastula and the beginning of transcription
reorganizes the spatio-temporal pattern of origin
firing, with replication occurring at specific sites every
150 –300 kb (primary source). In spite of this flexibility
in the distribution of active origins along the genome, the
total number of origins is a crucial parameter for the
efficient duplication of the genome (Machida et al., 2005
Shechter and Gautier, 2005)." |
| Entered by |
Uri M |
| ID |
111193 |