Distance on DNA between nonspecific replication sites in early embryo

Range 5 - 15 kb
Organism African clawed frog Xenopus laevis
Reference Conti C, Saccà B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell. 2007 Aug18(8):3059-67. p.3059 right column 2nd paragraphPubMed ID17522385
Comments "In early Xenopus embryos, transcription is repressed and DNA replication starts at nonspecific sites every 5–15 kb. The exit from midblastula and the beginning of transcription reorganizes the spatio-temporal pattern of origin firing, with replication occurring at specific sites every 150 –300 kb (Hyrien et al., 1995). In spite of this flexibility in the distribution of active origins along the genome, the total number of origins is a crucial parameter for the efficient duplication of the genome (Machida et al., 2005 Shechter and Gautier, 2005)."
Entered by Uri M
ID 111192