Fraction of spore dry weight that is pyridine-2,6-dicarboxylic acid (dipicolinic acid [DPA])

Range ~10 %
Organism Bacteria Bacillus subtilis
Reference Slieman TA, Nicholson WL. Role of dipicolinic acid in survival of Bacillus subtilis spores exposed to artificial and solar UV radiation. Appl Environ Microbiol. 2001 Mar67(3):1274-9. p.1274 abstract & right column bottom paragraphPubMed ID11229921
Primary Source [14] Murrell, W. G. 1967. The biochemistry of the bacterial spore. Adv. Microb. Physiol. 1: 133–251. [15] Murrell, W. G., and A. D. Warth. 1965. Composition and heat resistance of bacterial spores, p. 1–24. In L. L. Campbell and H. O. Halvorson (ed.), Spores III. American Society for Microbiology, Washington, D.C.
Comments "Pyridine-2,6-dicarboxylic acid (dipicolinic acid [DPA]) constitutes approximately 10% of Bacillus subtilis spore dry weight and has been shown to play a significant role in the survival of B. subtilis spores exposed to wet heat and to 254-nm UV radiation in the laboratory...Another factor implicated in spore resistance properties and germination is the small molecule pyridine-2,6-dicarboxylic acid (dipicolinic acid [DPA]). The Ca2+ chelate of DPA (Ca- DPA) is a major constituent of the dormant spore core, accounting for approximately 10% of total spore dry weight (primary sources)."
Entered by Uri M
ID 111172