Number of copies of each of protein components of nuclear pore complexes (npc)

Range 8 - 56 protein copies/NPC
Organism Eukaryotes
Reference Adam SA. The nuclear pore complex. Genome Biol. 2001 2(9):REVIEWS0007. p.3 right column top paragraphPubMed ID11574060
Comments "A major leap forward in the analysis of nucleoporins and NPC structure was the result of a convergence of two lines of research. First, completion of the yeast genome made it possible to identify likely NPC proteins by sequence similarity to known nucleoporins. Second, purification of the yNPC [yeast NPC] by Rout and colleagues made possible the potential identification of all pore-complex proteins by a proteomics analysis [2,27]. Surprisingly, they found that the yNPC is composed of only about 30 proteins, far fewer than the original estimates, with each protein present in 8 to 56 copies per pore."
Entered by Uri M
ID 111131