Cytosolic pH (pHc) dynamics during growth

Range Figure - link
Organism Budding yeast Saccharomyces cerevisiae
Reference Orij R et al., Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol. 2012 Sep 10 13(9):R80. doi: 10.1186/gb-2012-13-9-r80. p.3 figure 1PubMed ID23021432
Method "[Researchers] assessed pHc in growing yeast cultures under batch conditions to reveal that pHc is not constant during growth. pHc was neutral in the beginning of the exponential growth phase, and then gradually dropped approximately 0.3 pH units in mid-to late exponential phase, before glucose was depleted. Upon glucose depletion pHc decreased to 5.5 (Figure 1a)."
Comments "Growth (filled triangles) and pHc (filled circles) were monitored during growth on glucose in microplates. Data points represent the average of 24 biological replicates, error bars represent standard deviations."
Entered by Uri M
ID 110927